DeMichele S J, Brown R G
Comp Biochem Physiol B. 1984;79(2):203-9. doi: 10.1016/0305-0491(84)90014-2.
There were marked differences between the levels of collagen (measured as hydroxyproline) and mucopolysaccharides (measured as hexosamine) found in embryonic chicks with genetic muscular dystrophy and their normal controls. The chief differences were that the dystrophic tissues (gastrocnemius muscle and tendon, pectoralis major and skin) had: (a) greater amounts of hexosamine early in embryonic development; (b) hydroxyproline levels that rose at a faster rate, yielding different slopes than their normal controls; (c) relatively greater amounts of hydroxyproline than hexosamine later in embryonic life (day 20). Connective tissue systems in muscles were preferentially affected. The connective tissue system associated with dystrophic tissues appeared to lag behind the normal rhythm pattern of embryological development. The changes in connective tissue metabolism observed in dystrophic chicks suggested that the collagen from dystrophic embryonic chicks may be of a different structure or composition than that found in the normals.
患有遗传性肌肉萎缩症的胚胎小鸡与其正常对照小鸡在胶原蛋白（以羟脯氨酸衡量）和黏多糖（以氨基己糖衡量）水平上存在显著差异。主要差异在于，营养不良组织（腓肠肌和肌腱、胸大肌和皮肤）具有：(a) 在胚胎发育早期含有更多的氨基己糖；(b) 羟脯氨酸水平上升速度更快，与正常对照相比斜率不同；(c) 在胚胎后期（第20天），羟脯氨酸含量相对于氨基己糖相对更多。肌肉中的结缔组织系统受到优先影响。与营养不良组织相关的结缔组织系统似乎落后于胚胎发育的正常节律模式。在营养不良小鸡中观察到的结缔组织代谢变化表明，来自营养不良胚胎小鸡的胶原蛋白可能在结构或组成上与正常小鸡不同。
