Regulation of experimental allergic encephalomyelitis. Part 5. Role of the recipient in suppressor cell induction.

Suppressor cells that regulate experimental allergic encephalomyelitis (EAE) are present in spleens of Lewis rats that have recovered from the disease, as demonstrated by adoptive transfer of suppression to normal recipients. However, lethally irradiated recipients (850 rad) of spleen cells from recovered donors are not protected against EAE. Indeed, onset of EAE is accelerated in these irradiated recipients. These findings suggest that the host participates in the suppression of EAE.