诱导性红细胞自身抗体的抑制依赖于Lyt 1细胞。
Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.
作者信息
Hutchings P, Marshall-Clarke S, Cooke A
出版信息
Immunology. 1985 Oct;56(2):269-73.
Abstract
When normal mice are immunized with rat RBC, autoantibodies to mouse red cells and antigen-specific suppressor cells are generated. Suppressor cell activity is found in T-enriched populations and suppresses only the induction of autoantibody, not ongoing or secondary autoantibody responses. Using antibodies lytic for either B cells or distinct T-cell subpopulations, we are able to show that suppression is dependent on the presence of Lyt 1+ T cells.
摘要
当正常小鼠用大鼠红细胞免疫时，会产生针对小鼠红细胞的自身抗体和抗原特异性抑制细胞。抑制细胞活性存在于富含T细胞的群体中，并且仅抑制自身抗体的诱导，而不抑制正在进行的或继发性自身抗体反应。使用对B细胞或不同T细胞亚群具有裂解作用的抗体，我们能够证明抑制作用依赖于Lyt 1+ T细胞的存在。
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本文引用的文献
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