诱导性红细胞自身抗体的抑制依赖于Lyt 1细胞。
Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.
作者信息
Hutchings P, Marshall-Clarke S, Cooke A
出版信息
Immunology. 1985 Oct;56(2):269-73.
Abstract
When normal mice are immunized with rat RBC, autoantibodies to mouse red cells and antigen-specific suppressor cells are generated. Suppressor cell activity is found in T-enriched populations and suppresses only the induction of autoantibody, not ongoing or secondary autoantibody responses. Using antibodies lytic for either B cells or distinct T-cell subpopulations, we are able to show that suppression is dependent on the presence of Lyt 1+ T cells.
摘要
当正常小鼠用大鼠红细胞免疫时，会产生针对小鼠红细胞的自身抗体和抗原特异性抑制细胞。抑制细胞活性存在于富含T细胞的群体中，并且仅抑制自身抗体的诱导，而不抑制正在进行的或继发性自身抗体反应。使用对B细胞或不同T细胞亚群具有裂解作用的抗体，我们能够证明抑制作用依赖于Lyt 1+ T细胞的存在。
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2
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Proc Natl Acad Sci U S A. 1984 Apr;81(8):2494-8. doi: 10.1073/pnas.81.8.2494.
3
Rat erythrocyte-induced anti-erythrocyte autoantibody production and control in normal mice.
Immunol Rev. 1981;55:55-87. doi: 10.1111/j.1600-065x.1981.tb00339.x.
4
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Infect Immun. 1984 Apr;44(1):97-102. doi: 10.1128/iai.44.1.97-102.1984.
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