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混合异种重建小鼠（B10 + F344大鼠----B10）对皮肤异种移植物特异性低反应性的体内和体外特征分析

In vivo and in vitro characterization of specific hyporeactivity to skin xenografts in mixed xenogeneically reconstituted mice (B10 + F344 rat----B10).

作者信息

Ildstad S T, Wren S M, Sharrow S O, Stephany D, Sachs D H

出版信息

J Exp Med. 1984 Dec 1;160(6):1820-35. doi: 10.1084/jem.160.6.1820.

DOI:10.1084/jem.160.6.1820
PMID:6239902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187530/
Abstract

Mixed xenogeneically reconstituted mice (F344 rat + C57BL/10Sn----C57BL/10Sn), which specifically retain F344 tail skin xenografts, were studied for the specificity of such hyporeactivity and for in vitro reactivity and immunocompetence. Survival of mixed reconstituted animals was excellent, without evidence for graft vs. host disease. Donor-type tail skin grafts were specifically prolonged (mean survival time = 80 d) in comparison with normal controls and syngeneically reconstituted animals. In vitro, such animals manifested specific hyporeactivity by mixed lymphocyte reaction and cell-mediated lympholysis to F344 rat and B10 cells, with normal response to third-party rat (Wistar-Furth) and mouse (B10.BR). Examination of lymphoid tissues with a fluorescence-activated cell sorter revealed low levels, if any, of donor-type cells detectable. This system offers a model for investigation of xenogeneic transplantation tolerance.

摘要

对混合异种重建小鼠（F344大鼠+C57BL/10Sn----C57BL/10Sn）进行了研究，这些小鼠特异性保留了F344尾部皮肤异种移植物，以研究这种低反应性的特异性以及体外反应性和免疫能力。混合重建动物的存活率很高，没有移植物抗宿主病的迹象。与正常对照和同基因重建动物相比，供体类型的尾部皮肤移植物存活时间显著延长（平均存活时间=80天）。在体外，此类动物通过混合淋巴细胞反应和细胞介导的淋巴细胞溶解对F344大鼠和B10细胞表现出特异性低反应性，而对第三方大鼠（Wistar-Furth）和小鼠（B10.BR）有正常反应。用荧光激活细胞分选仪检查淋巴组织发现，即使能检测到，供体类型细胞的水平也很低。该系统为异种移植耐受性的研究提供了一个模型。

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J Immunol. 1980 Jul;125(1):129-35.

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