Stone A R, Hargreave T B, Chisholm G D
Br J Urol. 1980 Dec;52(6):535-8. doi: 10.1111/j.1464-410x.1980.tb03109.x.
The criteria for the diagnosis of progression of prostatic cancer after primary treatment by androgen suppression (oestrogen escape) were studied in 30 patients. Objective criteria are essential for this diagnosis and in this study the bone scan was the most useful criterion. Twenty-one of these patients had a secondary orchiectomy: one patient showed a partial objective response and 3 had a subjective response. It is concluded that an orchiectomy following failed primary oestrogen therapy is an ineffective procedure and therefore unjustifiable and that alternative treatments must continue to be evaluated.
对30例经雄激素抑制（雌激素逃逸）进行初始治疗后的前列腺癌进展诊断标准进行了研究。该诊断需要客观标准，在本研究中骨扫描是最有用的标准。其中21例患者接受了二次睾丸切除术：1例患者显示部分客观缓解，3例有主观缓解。得出的结论是，初始雌激素治疗失败后进行睾丸切除术是无效的程序，因此不合理，必须继续评估替代治疗方法。
