犬肝同种异体移植的活性增强——泼尼松龙预处理和供体特异性抗原的作用
Active enhancement of canine liver allografts--effect of pretreatment with prednisolone and donor-specific antigen.
作者信息
Lie T S, Nakano H, Bumanowski W, Rommelsheim K
出版信息
Surgery. 1976 Nov;80(5):565-8.
We investigated the active enhancement of liver allografts in 44 pairs of beagle dogs by pretreatment with semisoluble and soluble donor-specific spleen antigens. If the antigen were administered together with prednisolone, time of survival was significantly prolonged--with soluble antigen by 36.8 +/- 5.9 days and with semisoluble antigen by more than 3 years. Antigen pretreatment alone or antigen in combination with postoperative treatment of minimal immunosuppressive drugs had no significant effects. We found no correlation between the titer of lymphocytotoxic antibodies in the serum of recipients at the time of transplantation and survival times.
我们通过用半溶性和可溶性供体特异性脾抗原进行预处理，研究了44对比格犬肝脏同种异体移植的活性增强情况。如果抗原与泼尼松龙一起给药，存活时间会显著延长——可溶性抗原可延长36.8±5.9天，半溶性抗原可延长超过3年。单独进行抗原预处理或抗原与术后最小免疫抑制药物治疗联合使用均无显著效果。我们发现移植时受体血清中淋巴细胞毒性抗体的滴度与存活时间之间没有相关性。
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