Lie T S, Nakano H, Holst A, Oehr P, Choo S Y
Z Immunitatsforsch Exp Klin Immunol. 1976 Apr;151(3):250-3.
In 32 beagles heterotopic renal allotransplantations and bilateral nephrectomies were carried out. Control animals (5 dogs) survived 9.4 +/- 1.6 days. 22 recipients were pretreated with donor-specific semisoluble spleen antigen; 5 recipients pretreated with the antigen alone (780 mg/kg body weight) survived 16.6 +/- 2.3 days. A pretreatment with antigen combined with 5 mg/kg body weight Prednisolone resulted in no significant prolongation of survival time (5 animals), but 5 dogs survived significantly longer after pretreatment with the antigen and 50 mg/kg body weight Prednisolone (27.4 +/- 2,7 days). In 5 recipients after preoperative application of 3 doses Prednisolone alone (50 mg/kg body weight each) no prolongation of survival time could be observed (10.2 +/- 0.7 days). We found no correlation between lymphocytotoxic antibody titre and survival time.
对32只比格犬进行了异位肾同种异体移植和双侧肾切除术。对照动物（5只狗）存活了9.4±1.6天。22只受体用供体特异性半溶性脾抗原进行预处理；5只仅用抗原（780mg/kg体重）预处理的受体存活了16.6±2.3天。抗原与5mg/kg体重泼尼松龙联合预处理未显著延长存活时间（5只动物），但5只狗在抗原与50mg/kg体重泼尼松龙联合预处理后存活时间显著延长（27.4±2.7天）。5只受体术前单独应用3剂泼尼松龙（每次50mg/kg体重）后未观察到存活时间延长（10.2±0.7天）。我们发现淋巴细胞毒性抗体滴度与存活时间之间没有相关性。
