大脑及相关结构中的心房利钠因子（ANF）结合位点。

Atrial natriuretic factor (ANF) binding sites in brain and related structures.

作者信息

Quirion R, Dalpé M, De Lean A, Gutkowska J, Cantin M, Genest J

出版信息

Peptides. 1984 Nov-Dec;5(6):1167-72. doi: 10.1016/0196-9781(84)90183-9.

Abstract

Visualization of [125I]ANF binding sites in rat brain by an autoradiographic technique demonstrated that these sites are highly localized in areas such as the olfactory bulb, subfornical organ, area postrema and nucleus tractus solitarius. This distribution suggests that certain cardiovascular effects of ANF could be centrally mediated and that the existence of brain ANF-related peptides should be considered. Finally, moderate densities of [125I]ANF binding sites are found in the rat and guinea pig eye while low densities are seen in pituitary and pineal gland.

摘要

通过放射自显影技术对大鼠脑中[125I]心房钠尿肽（ANF）结合位点的可视化显示，这些位点高度集中在嗅球、穹窿下器官、最后区和孤束核等区域。这种分布表明ANF的某些心血管效应可能是由中枢介导的，并且应该考虑脑内ANF相关肽的存在。最后，在大鼠和豚鼠的眼中发现了中等密度的[125I]ANF结合位点，而在垂体和松果体中则发现低密度的结合位点。