λ噬菌体和P22噬菌体阻遏物。

The lambda and P22 phage repressors.

作者信息

Sauer R T, Nelson H C, Hehir K, Hecht M H, Gimble F S, DeAnda J, Poteete A R

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

J Biomol Struct Dyn. 1983 Dec;1(4):1011-22. doi: 10.1080/07391102.1983.10507499.

DOI:10.1080/07391102.1983.10507499

PMID:6242868

Abstract

The lambda cI repressor and the P22 c2 repressor contain two structural domains. In both proteins, the N-terminal domains mediate operator recognition and positive control of transcription, and the C-terminal domains mediate subunit oligomerization and recognition of the recA protein. In some cases, structural, biochemical, and genetic studies implicate particular repressor side chains in these processes.

摘要

λ cI 阻遏蛋白和 P22 c2 阻遏蛋白包含两个结构域。在这两种蛋白质中，N 端结构域介导操纵子识别和转录的正调控，C 端结构域介导亚基寡聚化以及对 recA 蛋白的识别。在某些情况下，结构、生化和遗传学研究表明特定的阻遏蛋白侧链参与了这些过程。