Antunes J L, Louis K, Cogen P, Zimmerman E A, Ferin M
Neuroendocrinology. 1980;30(2):76-82. doi: 10.1159/000122979.
The effects of pituitary stalk section on anterior pituitary morphology were studied in 18 female rhesus monkeys. 4 animals were studied within 1--14 days after the operation, while the others were examined later (average 17.2 months). In 3 monkeys there was no necrosis of the anterior lobe, whereas in the remaining animals, an area of infarction averaging 20% was found. Using immunocytochemical techniques, we found that corticotropes and somatotropes were still present following the procedure, and that the number of lactotropes increased markedly. In contrast, gonadotropes, although present in the pars tuberalis, were no longer demonstrable in the pars distalis 3 weeks after stalk section. These results show remarkable agreement between endocrine studies and morphological observations, and indicate a variable degree of dependency of the various pituitary cells on central nervous system influences.
在18只雌性恒河猴身上研究了垂体柄切断对垂体前叶形态的影响。4只动物在手术后1至14天内接受研究，其余动物则在稍后时间（平均17.2个月）接受检查。3只猴子的前叶没有坏死，而在其余动物中，发现平均梗死面积为20%。使用免疫细胞化学技术，我们发现手术后促肾上腺皮质激素细胞和生长激素细胞仍然存在，并且催乳激素细胞的数量显著增加。相比之下，促性腺激素细胞虽然存在于结节部，但在垂体柄切断3周后在远侧部不再能够检测到。这些结果表明内分泌研究与形态学观察结果非常一致，并表明各种垂体细胞对中枢神经系统影响的依赖程度各不相同。
