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抗哮喘药物治疗与钙离子：钙的发病机制及作用综述

Antiasthmatic drug therapy and calcium ions: review of pathogenesis and role of calcium.

作者信息

Middleton E

出版信息

J Pharm Sci. 1980 Feb;69(2):243-51. doi: 10.1002/jps.2600690244.

DOI:10.1002/jps.2600690244
PMID:6244384
Abstract

This paper presents the calcium-dependent pathophysiological features of allergic and nonallergic asthma. Various theories concerning the role of free calcium ions in the pathogenesis of asthma are discussed.

摘要

本文介绍了过敏性和非过敏性哮喘的钙依赖性病理生理特征。讨论了关于游离钙离子在哮喘发病机制中作用的各种理论。

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Antiasthmatic drug therapy and calcium ions: review of pathogenesis and role of calcium.抗哮喘药物治疗与钙离子：钙的发病机制及作用综述
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Pathogenesis of asthma: a review.哮喘的发病机制：综述
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[Effect on beta adrenergic receptors of tachyphylaxis on the sensitivity of smooth muscle in the bronchi to beta adrenergic receptor agonists in bronchial asthma].[速发耐受性对支气管哮喘患者支气管平滑肌对β肾上腺素能受体激动剂敏感性的β肾上腺素能受体的影响]
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Molecular mechanisms of beta-adrenergic relaxation of airway smooth muscle.气道平滑肌β-肾上腺素能舒张的分子机制。
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Nocturnal asthma: not a separate disease entity.夜间哮喘：并非一个独立的疾病实体。
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The extracellular deposition of mast cell products is increased in hypertrophic airways smooth muscles in allergic asthma but not in nonallergic asthma.在过敏性哮喘中，肥大细胞产物的细胞外沉积在肥厚的气道平滑肌中增加，但在非过敏性哮喘中则不然。
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The beta-agonist controversy revisited.β-激动剂争议再探讨。
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Subnormal inhibition of active E rosette formation by isoproterenol in bronchial asthma.支气管哮喘中异丙肾上腺素对活性E玫瑰花结形成的抑制作用减弱。
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1980 Jun;13(2):128-37.

引用本文的文献

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Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial.镁雾化吸入治疗小儿哮喘（MagNUM PA）试验：一项随机对照试验的研究方案
Trials. 2016 May 24;17(1):261. doi: 10.1186/s13063-015-1151-x.
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The early asthmatic response is associated with glycolysis, calcium binding and mitochondria activity as revealed by proteomic analysis in rats.蛋白质组学分析显示，大鼠的早期哮喘反应与糖酵解、钙结合和线粒体活性有关。
Respir Res. 2010 Aug 6;11(1):107. doi: 10.1186/1465-9921-11-107.
3
Comparison of nebulised magnesium sulphate and salbutamol combined with salbutamol alone in the treatment of acute bronchial asthma: a randomised study.
雾化硫酸镁与沙丁胺醇联合单用沙丁胺醇治疗急性支气管哮喘的比较：一项随机研究。
Emerg Med J. 2006 May;23(5):358-62. doi: 10.1136/emj.2005.026203.
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Efficacy of calcium channel blockers as maintenance therapy for asthma.钙通道阻滞剂作为哮喘维持治疗的疗效。
Br J Clin Pharmacol. 2002 Mar;53(3):243-9. doi: 10.1046/j.0306-5251.2001.01560.x.
5
Intracellular (polymorphonuclear) magnesium content in patients with bronchial asthma between attacks.支气管哮喘发作间期患者的细胞内（多形核）镁含量
J R Soc Med. 1995 Aug;88(8):441-5.
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A calcium antagonist, nifedipine, modifies exercise-induced asthma.钙拮抗剂硝苯地平可改善运动诱发的哮喘。
Thorax. 1981 Oct;36(10):726-30. doi: 10.1136/thx.36.10.726.
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Effect of nifedipine on constriction of human tracheal strips in vitro.硝苯地平对人离体气管条收缩的影响。
Br J Pharmacol. 1983 Apr;78(4):687-91. doi: 10.1111/j.1476-5381.1983.tb09421.x.
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Effects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma.钙通道阻滞对轻度哮喘患者组胺诱导的支气管收缩的影响。
Thorax. 1984 Aug;39(8):572-5. doi: 10.1136/thx.39.8.572.
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Inhibition of rat mast cell degranulation by verapamil.维拉帕米对大鼠肥大细胞脱颗粒的抑制作用。
Agents Actions. 1984 Feb;14(2):153-6. doi: 10.1007/BF01966635.
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Calcium-channel blockers and asthma.钙通道阻滞剂与哮喘
Thorax. 1983 Jul;38(7):481-5. doi: 10.1136/thx.38.7.481.