支气管哮喘发作间期患者的细胞内（多形核）镁含量
Intracellular (polymorphonuclear) magnesium content in patients with bronchial asthma between attacks.
作者信息
Fantidis P, Ruiz Cacho J, Marín M, Madero Jarabo R, Solera J, Herrero E
机构信息
Department of Research Unit--Experimental Surgery, Hospital La Paz, School of Medicine, Universidad Autónoma, Madrid, Spain.
出版信息
J R Soc Med. 1995 Aug;88(8):441-5.
Previous studies have demonstrated the role of polymorphonuclears in asthma, the importance of increases in intracellular concentrations of ionized calcium in the release of chemical mediators, the role of magnesium as natural calcium channel blocker, and the importance of magnesium deficiency in plasma histamine concentration and in tissue prostanoid concentration. The objective of our study was to measure the polymorphonuclear magnesium content in patients with asthma in the interval between attacks. We measured the polymorphonuclear magnesium content, and serum and erythrocyte sodium, calcium, and magnesium concentrations in 21 healthy volunteers and 50 patients with different types of asthma. In our patients, the polymorphonuclear magnesium content was lower than in the control group (P < 0.001), while magnesium levels in erythrocytes and serum and the levels of other ions in erythrocytes and serum were normal. This is the first report to document low polymorphonuclear magnesium content in patients with bronchial asthma. The reduction of polymorphonuclear magnesium content may have an important role in the pathogenesis of asthma.
先前的研究已证明多形核白细胞在哮喘中的作用、细胞内游离钙浓度升高在化学介质释放中的重要性、镁作为天然钙通道阻滞剂的作用，以及血浆组胺浓度和组织类前列腺素浓度中镁缺乏的重要性。我们研究的目的是在发作间歇期测量哮喘患者多形核白细胞中的镁含量。我们测量了21名健康志愿者和50名不同类型哮喘患者的多形核白细胞镁含量、血清和红细胞中的钠、钙和镁浓度。在我们的患者中，多形核白细胞镁含量低于对照组（P < 0.001），而红细胞和血清中的镁水平以及红细胞和血清中其他离子的水平正常。这是首份记录支气管哮喘患者多形核白细胞镁含量降低的报告。多形核白细胞镁含量的降低可能在哮喘发病机制中起重要作用。
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