糖皮质激素对人体胃泌素分泌的影响。
Effect of glucocorticoids on gastrin secretion in man.
作者信息
Seino S, Seino Y, Matsukura S, Kurahachi H, Ikeda M, Yawata M, Imura H
出版信息
Gut. 1978 Jan;19(1):10-3. doi: 10.1136/gut.19.1.10.
Abstract
In order to investigate the effect of glucocorticoids on gastrin secretion, plasma gastrin levels were measured by radioimmunoassay in patients with Cushing's syndrome and those treated with glucocorticoids. Fasting plasma gastrin levels were significantly higher in these patients than in normal subjects, with exaggerated response to food. Conversely, short-term treatment or intravenous infusion of glucocorticoids had no significant influence on gastrin secretion in normal subjects. The possible mechanism by which glucocorticoids cause hypergastrinaemia are discussed.
摘要
为了研究糖皮质激素对胃泌素分泌的影响，我们采用放射免疫分析法测定了库欣综合征患者及接受糖皮质激素治疗患者的血浆胃泌素水平。这些患者的空腹血浆胃泌素水平显著高于正常受试者，且对食物的反应增强。相反，短期治疗或静脉输注糖皮质激素对正常受试者的胃泌素分泌没有显著影响。本文讨论了糖皮质激素导致高胃泌素血症的可能机制。
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