热带吸收不良中的肠道激素
Gut hormones in tropical malabsorption.
作者信息
Besterman H S, Cook G C, Sarson D L, Christofides N D, Bryant M G, Gregor M, Bloom S R
出版信息
Br Med J. 1979 Nov 17;2(6200):1252-5. doi: 10.1136/bmj.2.6200.1252.
Abstract
Concentrations of various gut hormones were measured after a test breakfast in eight patients with severe tropical malabsorption and 12 controls. The patients with tropical malabsorption had greatly raised basal plasma motilin and enteroglucagon concentrations, but their postprandial release of both gastric inhibitory polypeptide and insulin was significantly reduced. The pattern of gut hormone release differed from that found in coeliac disease. The measurement of gut hormones, each of which has a specific site and function, thus throws new light on the pathophysiology of tropical malabsorption and may suggest approaches of treatment.
摘要
对8名严重热带吸收不良患者和12名对照者在进行试验早餐后测定了各种肠道激素的浓度。热带吸收不良患者的基础血浆胃动素和肠高血糖素浓度大幅升高，但他们餐后胃抑制多肽和胰岛素的释放均显著减少。肠道激素释放模式与乳糜泻不同。由于每种肠道激素都有特定的作用部位和功能，因此对肠道激素的测定为热带吸收不良的病理生理学提供了新的线索，并可能提示治疗方法。
相似文献
1
Gut hormones in tropical malabsorption.热带吸收不良中的肠道激素
Br Med J. 1979 Nov 17;2(6200):1252-5. doi: 10.1136/bmj.2.6200.1252.
2
Gut hormones in acute diarrhoea.急性腹泻中的肠道激素
Gut. 1983 Jul;24(7):665-71. doi: 10.1136/gut.24.7.665.
3
[Coeliac sprue and gut hormones: pathophysiological and clinical aspects (author's transl)].[乳糜泻与肠道激素：病理生理及临床方面（作者译）]
Z Gastroenterol. 1981 Dec;19(12):756-66.
4
Pancreatic and gastrointestinal hormones in chronic pancreatitis.慢性胰腺炎中的胰腺和胃肠激素
Digestion. 1982;24(3):195-208. doi: 10.1159/000198797.
5
Gut hormone responses in subjects with a permanent ileostomy.永久性回肠造口术患者的肠道激素反应。
Digestion. 1982;24(2):133-6. doi: 10.1159/000198788.
6
Gut hormone release after intestinal resection.肠道切除术后肠道激素的释放
Gut. 1982 Oct;23(10):854-61. doi: 10.1136/gut.23.10.854.
7
Somatostatin-14 modulates postprandial glucose levels and release of gastrointestinal and pancreatic hormones.生长抑素-14调节餐后血糖水平以及胃肠和胰腺激素的释放。
Digestion. 1985;31(4):234-42. doi: 10.1159/000199205.
8
Effect of motilin on the rate of gastric emptying and gut hormone release during breakfast.胃动素对早餐期间胃排空速率和肠道激素释放的影响。
Gastroenterology. 1979 May;76(5 Pt 1):903-7.
9
Plasma enteroglucagon related to malabsorption in coeliac disease.乳糜泻中与吸收不良相关的血浆肠高血糖素
Gut. 1984 Jun;25(6):629-35. doi: 10.1136/gut.25.6.629.
10
Gut-hormone profile in totally pancreatectomised patients.全胰切除患者的肠道激素谱
Gut. 1981 Feb;22(2):103-7. doi: 10.1136/gut.22.2.103.
引用本文的文献
1
Glucose-dependent insulinotropic polypeptide (GIP).葡萄糖依赖性促胰岛素多肽（GIP）。
Mol Metab. 2025 May;95:102118. doi: 10.1016/j.molmet.2025.102118. Epub 2025 Feb 28.
2
Association of human gut microbiota with rare diseases: A close peep through.人类肠道微生物群与罕见病的关联：深入探究
Intractable Rare Dis Res. 2022 May;11(2):52-62. doi: 10.5582/irdr.2022.01025.
3
Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment.双重葡萄糖依赖性促胰岛素多肽（GIP）/胰高血糖素样肽-1受体激动剂（双促肠促胰岛素）在血糖控制中的作用：从病理生理学到治疗
Life (Basel). 2021 Dec 25;12(1):29. doi: 10.3390/life12010029.
4
The Gut-Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation.肠-脑轴及其在肠道炎症中控制进食行为的作用。
Nutrients. 2021 Mar 18;13(3):981. doi: 10.3390/nu13030981.
5
Tropical sprue in 2014: the new face of an old disease.2014年的热带口炎性腹泻：一种古老疾病的新面貌。
Curr Gastroenterol Rep. 2014;16(6):391. doi: 10.1007/s11894-014-0391-3.
6
Action and therapeutic potential of oxyntomodulin.胃泌酸调节素的作用及治疗潜力。
Mol Metab. 2013 Dec 14;3(3):241-51. doi: 10.1016/j.molmet.2013.12.001. eCollection 2014 Jun.
7
Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease.综述文章：胃肠道、胆汁酸和肠促胰岛素在糖尿病和非酒精性脂肪性肝病发病机制中的新兴相互作用。
Aliment Pharmacol Ther. 2012 Nov;36(10):909-21. doi: 10.1111/apt.12084. Epub 2012 Oct 11.
8
Unraveling oxyntomodulin, GLP1's enigmatic brother.揭开胰高血糖素样肽-1 神秘兄弟——奥曲肽的面纱。
J Endocrinol. 2012 Dec;215(3):335-46. doi: 10.1530/JOE-12-0368. Epub 2012 Sep 27.
9
Nutrient detection by incretin hormone secreting cells.肠促胰岛素分泌细胞的营养物质检测。
Physiol Behav. 2012 Jun 6;106(3):387-93. doi: 10.1016/j.physbeh.2011.12.001. Epub 2011 Dec 13.
10
Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats.在瘦大鼠中，膳食碳水化合物而非蛋白质的剂量增加会引起肠促胰岛素激素 GIP 和 GLP-1 的不同反应。
Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G476-85. doi: 10.1152/ajpgi.00432.2009. Epub 2010 Jun 3.
本文引用的文献
1
Production and excretion of hydrogen gas in man.人体中氢气的产生与排泄
N Engl J Med. 1969 Jul 17;281(3):122-7. doi: 10.1056/NEJM196907172810303.
2
3
Tropical sprue.热带口炎性腹泻
Gut. 1969 May;10(5):328-33. doi: 10.1136/gut.10.5.328.
4
Studies of intestinal microflora. II. Microorganisms of the small intestine and their relations to oral and fecal flora.肠道微生物群的研究。II. 小肠微生物及其与口腔和粪便菌群的关系。
Gastroenterology. 1967 Dec;53(6):856-67.
5
Enterotoxigenic intestinal bacteria in tropical sprue.热带口炎性腹泻中的产肠毒素肠道细菌
Ann Intern Med. 1973 Nov;79(5):632-41. doi: 10.7326/0003-4819-79-5-632.
6
Serum antibodies and jejunal histology in giardiasis associated with malabsorption.与吸收不良相关的贾第虫病中的血清抗体和空肠组织学
J Clin Pathol. 1976 Jan;29(1):30-4. doi: 10.1136/jcp.29.1.30.
7
The amino acid sequence of a hypothalamic peptide, neurotensin.一种下丘脑肽——神经降压素的氨基酸序列。
J Biol Chem. 1975 Mar 10;250(5):1907-11.
8
Gastrin (second of two parts).胃泌素（两部分中的第二部分）。
N Engl J Med. 1975 Jun 26;292(26):1377-84. doi: 10.1056/NEJM197506262922605.
9
Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.13-去甲亮氨酸胃动素对人体的作用——抑制胃排空及刺激胃蛋白酶分泌
Scand J Gastroenterol. 1975;10(2):199-202.
10
Current problems in the measurement of gastrin release. A reproducible measure of physiological gastrin release.胃泌素释放测量中的当前问题。生理胃泌素释放的可重复测量方法。
Postgrad Med J. 1976 Oct;52(612):645-50. doi: 10.1136/pgmj.52.612.645.
Zotero 插件