Tyrey L
J Pharmacol Exp Ther. 1980 May;213(2):306-8.
To determine if delta 9-tetrahydrocannabinol (THC) dosages comparable to those obtainable from marihuana cigarettes suppress episodic luteinizing hormone (LH) secretion, THC was administered to ovariectomized rats in doses of 31.2 to 500 microgram/kg b.wt. THC in doses of 62.5 microgram/kg b.wt. or greater rapidly suppressed episodic LH release and reduced serum LH concentrations by 42 to 68%. The period of suppression ranged from less than 30 min to more than 1 hr and was dose-dependent. These results indicate that acute exposure to relatively low doses of THC significantly disrupts gonadotropic hormone secretion in the rat and raise the question of whether episodic LH secretion in humans might be suppressed subsequent to the use of marihuana.
为了确定与从大麻卷烟中获取的剂量相当的δ9 - 四氢大麻酚（THC）剂量是否会抑制促黄体生成素（LH）的阵发性分泌，将THC以31.2至500微克/千克体重的剂量给予去卵巢大鼠。62.5微克/千克体重及以上剂量的THC迅速抑制LH的阵发性释放，并使血清LH浓度降低42%至68%。抑制期从不到30分钟到超过1小时不等，且呈剂量依赖性。这些结果表明，急性暴露于相对低剂量的THC会显著扰乱大鼠促性腺激素的分泌，并引发一个问题，即人类在使用大麻后LH的阵发性分泌是否会受到抑制。
