Dalterio S L, Mayfield D L, Bartke A
Subst Alcohol Actions Misuse. 1983;4(5):339-45.
Gonadectomy resulted in a gradual increase in plasma gonadotropin levels in female mice. At certain intervals after ovariectomy, a single administration of delta 9-tetrahydrocannabinol (THC; 50 mg/kg) reduced plasma levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), while at other times THC had no effect. Administration of THC significantly reduced plasma concentrations of LH and FSH in intact diestrous females. In an additional study, in intact diestrous females injected with testosterone propionate (TP; 125 micrograms), concommitant exposure to THC did not affect plasma testosterone (T) levels, but plasma dihydrotestosterone (DHT) levels at 20 and 60 min were significantly higher in animals receiving TP and THC. Administration of THC can alter pituitary gonadotropin release in intact diestrous and in ovariectomized female mice. Effects of THC on plasma androgen levels after exogeneous treatment with TP suggest that THC can alter metabolism or target tissue response to gonadal steroids.
去势导致雌性小鼠血浆促性腺激素水平逐渐升高。在卵巢切除术后的特定时间间隔，单次给予Δ⁹-四氢大麻酚（THC；50毫克/千克）可降低黄体生成素（LH）和促卵泡激素（FSH）的血浆水平，但在其他时间THC没有效果。给予THC可显著降低处于动情后期的未切除卵巢雌性小鼠的LH和FSH血浆浓度。在另一项研究中，给处于动情后期的未切除卵巢雌性小鼠注射丙酸睾酮（TP；125微克），同时暴露于THC下并不影响血浆睾酮（T）水平，但在接受TP和THC的动物中，20分钟和60分钟时的血浆双氢睾酮（DHT）水平显著更高。给予THC可改变处于动情后期的未切除卵巢和去卵巢雌性小鼠的垂体促性腺激素释放。THC对外源性给予TP后血浆雄激素水平的影响表明，THC可改变性腺类固醇的代谢或靶组织反应。
