Rosenberg N, Witte O N
J Virol. 1980 Jan;33(1):340-8. doi: 10.1128/JVI.33.1.340-348.1980.
Abelson murine leukemia virus (A-MuLV) is a replication-defective virus that transforms both fibroblasts and hematopoietic cells in vitro. The virus encodes a 120,000-molecular-weight protein (P120) that is composed of Moloney murine leukemia virus-derived gag gene sequences and A-MuLV--specific sequences. This protein is the only A-MuLV--encoded protein that has been detected, and thus P120 is a candidate for the transforming protein of A-MuLV. We now report isolation and characterization of three new A-MuLV isolates that do not synthesize P120 but do produce analogous proteins of larger (160,000 molecular weight) and smaller (100,000 and 90,000 molecular weight) size. All of these A-MuLV isolates transform fibroblasts and lymphoid cells in vitro. Because the different A-MuLV proteins vary in the A-MuLV--specific region of the molecule, these variants may set a maximum limit on the size of the A-MuLV transforming protein.
阿贝尔森鼠白血病病毒（A-MuLV）是一种复制缺陷型病毒，可在体外转化成纤维细胞和造血细胞。该病毒编码一种分子量为120,000的蛋白质（P120），它由莫洛尼鼠白血病病毒衍生的gag基因序列和A-MuLV特异性序列组成。这种蛋白质是已检测到的唯一一种A-MuLV编码蛋白，因此P120是A-MuLV转化蛋白的候选者。我们现在报告了三种新的A-MuLV分离株的分离和特性，这些分离株不合成P120，但确实产生了更大（160,000分子量）和更小（100,000和90,000分子量）的类似蛋白。所有这些A-MuLV分离株均可在体外转化成纤维细胞和淋巴细胞。由于不同的A-MuLV蛋白在分子的A-MuLV特异性区域有所不同，这些变体可能为A-MuLV转化蛋白的大小设定了最大限制。
