Zamansky G B, Kleinman L F, Black P H, Kaplan J C
Mutat Res. 1980 Mar;70(1):1-9. doi: 10.1016/0027-5107(80)90052-4.
The reactivation of UV-irradiated herpes simplex virus (HSV) was investigated in irradiated and unirradiated transformed hamster cells in which infectious simian virus 40 (SV40) can be induced. Reactivation was enhanced when the cells were treated with UV light or mitomycin C prior to infection with HSV. The IV dose-response curve of this enhanced reactivation was strikingly similar to that found for induction of SV40 virus synthesis in cells treated under identical condictions. This is the first time that two SOS functions described in bacteria have been demonstrated in a single mammalian cell line.
在可诱导感染性猿猴病毒40（SV40）的经照射和未经照射的转化仓鼠细胞中，研究了紫外线照射的单纯疱疹病毒（HSV）的复活情况。在用HSV感染之前，先用紫外线或丝裂霉素C处理细胞，复活作用会增强。这种增强的复活作用的紫外线剂量-反应曲线与在相同条件下处理的细胞中诱导SV40病毒合成所发现的曲线惊人地相似。这是首次在单一哺乳动物细胞系中证明了细菌中描述的两种SOS功能。
