单纯疱疹病毒的紫外线复活在哺乳动物细胞中具有致突变性且可诱导。
Ultraviolet reactivation of herpes simplex virus is mutagenic and inducible in mammlian cells.
作者信息
DasGupta U B, Summers W C
出版信息
Proc Natl Acad Sci U S A. 1978 May;75(5):2378-81. doi: 10.1073/pnas.75.5.2378.
Abstract
The survival of UV-irradiated herpes simplex virus on UV-irradiated Vero cells was increased over that on unirradiated cells. A time period between irradiation of the host cells and infection with virus was needed to achieve maximum reactivation. In parallel experiments in which the frequencies of occurrence of the forward mutation in the thymidine kinase gene of the virus were measured, growth of herpes simplex virus on UV-irradiated cells yielded progeny virus that had higher frequencies of TK- mutants than did progeny from infections of control cells. The time course of development of this mutagenic effect was the same as that for the development of the UV-reactivation capacity. Furthermore, development of the UV reactivation could be blocked by inhibition of protein synthesis. These results suggest that an "error prone" inducible UV-reactivation phenomenon exists in mammalian cells.
摘要
紫外线照射的单纯疱疹病毒在紫外线照射的非洲绿猴肾细胞上的存活率高于在未照射细胞上的存活率。在宿主细胞照射和病毒感染之间需要一个时间段以实现最大程度的复活。在平行实验中，测定了病毒胸苷激酶基因正向突变的发生频率，结果发现单纯疱疹病毒在紫外线照射的细胞上生长产生的子代病毒中，胸苷激酶缺陷型（TK-）突变体的频率高于对照细胞感染产生的子代病毒。这种诱变效应的发展时间进程与紫外线复活能力的发展时间进程相同。此外，蛋白质合成的抑制可阻断紫外线复活的发生。这些结果表明，在哺乳动物细胞中存在一种“易错”的可诱导紫外线复活现象。
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