灵长类动物实验性胶质瘤：一种计算机断层扫描模型。

Experimental glioma in primates: a computed tomography model.

作者信息

Rieth K G, Di Chiro G, London W T, Sever J L, Houff S A, Kornblith P L, McKeever P E, Buonomo C, Padgett B L, Walker D L

出版信息

J Comput Assist Tomogr. 1980 Jun;4(3):285-90. doi: 10.1097/00004728-198006000-00001.

DOI:10.1097/00004728-198006000-00001

PMID:6246149

Abstract

Owl and squirrel monkeys inoculated intracerebrally with human polyomavirus obtained from the brain of patient with progressive multifocal leukoencephalopathy developed cerebral gliomas. Among these tumors, three out of five were detected and accurately localized by contrast enhanced computed tomography (CT) when the animals were still clinically normal. Various CT features of these tumors corresponded to specific pathologic changes, such as histologic type and presence of hemorrhage and necrosis. Also, tumor progression was clearly demonstrated in repeat scans of one animal. The CT sensitivity and the capability of distinguishing various pathologic features are encouraging. It appears that a much needed, suitable model of experimental cerebral tumors in primates is now available for CT studies.

摘要

用从进行性多灶性白质脑病患者大脑中获取的人类多瘤病毒进行脑内接种的猫头鹰猴和松鼠猴发生了脑胶质瘤。在这些肿瘤中，当动物临床上仍正常时，五分之三的肿瘤通过对比增强计算机断层扫描（CT）被检测到并准确定位。这些肿瘤的各种CT特征与特定的病理变化相对应，如组织学类型以及出血和坏死的存在情况。此外，在对一只动物的重复扫描中清楚地显示了肿瘤的进展。CT的敏感性以及区分各种病理特征的能力令人鼓舞。看来现在有了一个灵长类动物急需的、合适的实验性脑肿瘤模型可用于CT研究。