Houff S A, London W T, Zu Rhein G M, Padgett B L, Walker D L, Sever J L
Prog Clin Biol Res. 1983;105:223-6.
Owl and squirrel monkeys are susceptible to the oncogenic effects of JCV. These species of New World monkeys can be safely inoculated intracerebrally. Care must be taken with owl monkeys since they have an inherited clotting abnormality. Incubation times for the development of tumors range from 14 to 30 months. Anorexia was the first clinical sign of tumor development. The clinical course is rapid with death within two to three days. This model provides a means for studying diagnostic, virological, immunological and therapeutic techniques which are applicable to human patients with astrocytomas.
猫头鹰猴和松鼠猴对多瘤病毒（JCV）的致癌作用敏感。这些新大陆猴种可以安全地进行脑内接种。对于猫头鹰猴必须格外小心，因为它们存在遗传性凝血异常。肿瘤发生的潜伏期为14至30个月。厌食是肿瘤发展的首个临床症状。临床病程进展迅速，两到三天内死亡。该模型为研究适用于星形细胞瘤患者的诊断、病毒学、免疫学和治疗技术提供了一种手段。
