人类多瘤病毒JC病毒基因组。
Human polyomavirus JC virus genome.
作者信息
Frisque R J, Bream G L, Cannella M T
出版信息
J Virol. 1984 Aug;51(2):458-69. doi: 10.1128/JVI.51.2.458-469.1984.
Abstract
The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence, called the agnoprotein in simian virus 40. The extent of homology between JC virus DNA and the genomes of simian virus 40 (69%) and BK virus (75%) confirmed the close evolutionary relationship of these three polyomaviruses. The sequences showing the greatest divergence in these viral DNAs occurred within the tandem repeats located to the late side of the replication origins.
摘要
本文展示了人类JC病毒的完整DNA序列，该序列由5130个核苷酸对组成。可以推导六种蛋白质的氨基酸序列：早期非结构蛋白大T抗原和小t抗原；晚期衣壳蛋白VP1、VP2和VP3；以及在晚期前导序列中编码的agnogene产物，在猴病毒40中称为agnoprotein。JC病毒DNA与猴病毒40基因组（69%）和BK病毒基因组（75%）之间的同源程度证实了这三种多瘤病毒之间密切的进化关系。这些病毒DNA中差异最大的序列出现在复制起点下游的串联重复序列中。
相似文献
1
Human polyomavirus JC virus genome.人类多瘤病毒JC病毒基因组。
J Virol. 1984 Aug;51(2):458-69. doi: 10.1128/JVI.51.2.458-469.1984.
2
Nucleotide sequence of the region encompassing the JC virus origin of DNA replication.包含JC病毒DNA复制起点区域的核苷酸序列。
J Virol. 1983 Apr;46(1):170-6. doi: 10.1128/JVI.46.1.170-176.1983.
3
Genomic structure of human polyoma virus JC: nucleotide sequence of the region containing replication origin and small-T-antigen gene.人类多瘤病毒JC的基因组结构：包含复制起点和小T抗原基因区域的核苷酸序列
J Virol. 1983 Jan;45(1):73-9. doi: 10.1128/JVI.45.1.73-79.1983.
4
Polyoma virus DNA: Sequence from the late region that specifies the leader sequence for late mRNA and codes for VP2, VP3, and the N-terminus of VP1.多瘤病毒DNA：来自晚期区域的序列，该序列指定晚期mRNA的前导序列，并编码VP2、VP3和VP1的N末端。
J Virol. 1980 Feb;33(2):606-18. doi: 10.1128/JVI.33.2.606-618.1980.
5
Analysis of capsid formation of human polyomavirus JC (Tokyo-1 strain) by a eukaryotic expression system: splicing of late RNAs, translation and nuclear transport of major capsid protein VP1, and capsid assembly.利用真核表达系统分析人多瘤病毒JC（东京-1株）的衣壳形成：晚期RNA的剪接、主要衣壳蛋白VP1的翻译与核转运以及衣壳组装
J Virol. 2000 Feb;74(4):1840-53. doi: 10.1128/jvi.74.4.1840-1853.2000.
6
Expression of novel proteins by polyomaviruses and recent advances in the structural and functional features of agnoprotein of JC virus, BK virus, and simian virus 40.多瘤病毒表达的新型蛋白及 JC 病毒、BK 病毒和猴多瘤病毒 40 病毒的 agnoprotein 的结构和功能特征的最新进展。
J Cell Physiol. 2019 Jun;234(6):8295-8315. doi: 10.1002/jcp.27715. Epub 2018 Nov 2.
7
Comparison of infectious JC virus DNAs cloned from human brain.从人脑中克隆的感染性JC病毒DNA的比较。
J Virol. 1983 Jan;45(1):299-308. doi: 10.1128/JVI.45.1.299-308.1983.
8
Extension of JC virus host range to monkey cells by insertion of a simian virus 40 enhancer into the JC virus regulatory region.通过将猿猴病毒40增强子插入JC病毒调控区域，使JC病毒宿主范围扩展至猴细胞。
Virology. 1989 Jun;170(2):353-61. doi: 10.1016/0042-6822(89)90425-x.
9
Polyoma virus DNA: complete nucleotide sequence of the gene which codes for polyoma virus capsid protein VP1 and overlaps the VP2/VP3 genes.多瘤病毒DNA：编码多瘤病毒衣壳蛋白VP1且与VP2/VP3基因重叠的基因的完整核苷酸序列。
J Virol. 1980 Feb;33(2):619-30. doi: 10.1128/JVI.33.2.619-630.1980.
10
Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40: identification of sequences important for efficient transformation.多瘤病毒JC病毒、BK病毒和猿猴病毒40的杂交基因组：对高效转化重要的序列鉴定
J Virol. 1989 Feb;63(2):863-72. doi: 10.1128/JVI.63.2.863-872.1989.
引用本文的文献
1
The presence of human polyomavirus JC (JCPyV) in pediatric brain tumors: a plausible trigger in Wnt/β-catenin pathway.小儿脑肿瘤中人类多瘤病毒JC（JCPyV）的存在：Wnt/β-连环蛋白通路中一个可能的触发因素。
J Neurovirol. 2025 Sep 17. doi: 10.1007/s13365-025-01274-7.
2
CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9.CRISPR抗病毒技术通过SaCas9的双gRNA切除作用在二维和三维培养模型中抑制嗜神经的JC多瘤病毒。
Mol Ther Nucleic Acids. 2025 May 14;36(2):102556. doi: 10.1016/j.omtn.2025.102556. eCollection 2025 Jun 10.
3
JC Polyomavirus in Prostate Cancer-Friend or Foe?前列腺癌中的JC多瘤病毒：是友还是敌？
Cancers (Basel). 2025 May 21;17(10):1725. doi: 10.3390/cancers17101725.
4
5
Target-specific peptides for BK virus agnoprotein identified through phage display screening: advancing antiviral therapeutics.通过噬菌体展示筛选鉴定出的针对BK病毒辅助蛋白的靶向特异性肽：推进抗病毒治疗
Sci Rep. 2025 Jan 21;15(1):2718. doi: 10.1038/s41598-025-86439-4.
6
Recent advances in discovery and functional analysis of the small proteins and microRNA expressed by polyomaviruses.多瘤病毒表达的小蛋白和微小RNA的发现及功能分析的最新进展。
Virology. 2025 Jan;602:110310. doi: 10.1016/j.virol.2024.110310. Epub 2024 Nov 22.
7
JC virus small tumor antigen promotes S phase entry and cell cycle progression.JC病毒小肿瘤抗原促进S期进入和细胞周期进程。
Tumour Virus Res. 2024 Dec;18:200298. doi: 10.1016/j.tvr.2024.200298. Epub 2024 Nov 23.
8
Directly Isolated Allogeneic Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy.进行性多灶性白质脑病中直接分离的同种异体病毒特异性T细胞
JAMA Neurol. 2024 Oct 7;81(11):1187-98. doi: 10.1001/jamaneurol.2024.3324.
9
Insights into the genetic characteristics, clustering patterns, and phylogeographic dynamics of the JC polyomavirus, 1993 to 2023.对 JC 多瘤病毒的遗传特征、聚类模式和系统地理学动态的深入了解，1993 年至 2023 年。
Virus Res. 2024 Aug;346:199414. doi: 10.1016/j.virusres.2024.199414. Epub 2024 Jun 12.
10
Polyomavirus Wakes Up and Chooses Neurovirulence.多瘤病毒苏醒并选择神经毒性。
Viruses. 2023 Oct 18;15(10):2112. doi: 10.3390/v15102112.
本文引用的文献
1
BK viral enhancer element and a human cellular homolog.BK病毒增强子元件和一种人类细胞同源物。
Science. 1983 Nov 18;222(4625):749-55. doi: 10.1126/science.6314501.
2
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.启动子特异性转录因子Sp1与SV40早期启动子中的上游序列结合。
Cell. 1983 Nov;35(1):79-87. doi: 10.1016/0092-8674(83)90210-6.
3
Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene.病毒辅助基因丝氨酸密码子中的错义突变对猴病毒40型VP1突变体的抑制作用
J Virol. 1983 Nov;48(2):405-9. doi: 10.1128/JVI.48.2.405-409.1983.
4
Sequence repeats in a polyoma virus DNA region important for gene expression.多瘤病毒DNA区域中对基因表达重要的序列重复。
J Virol. 1983 Jul;47(1):233-7. doi: 10.1128/JVI.47.1.233-237.1983.
5
Simian virus 40 tumor antigen: isolation of the origin-specific DNA-binding domain.猿猴病毒40肿瘤抗原：起源特异性DNA结合结构域的分离
J Virol. 1983 Jul;47(1):106-14. doi: 10.1128/JVI.47.1.106-114.1983.
6
Regulatory sequences and virus-cell interactions of JC virus.JC病毒的调控序列与病毒-细胞相互作用
Prog Clin Biol Res. 1983;105:41-59.
7
Definition of the simian virus 40 early promoter region and demonstration of a host range bias in the enhancement effect of the simian virus 40 72-base-pair repeat.猿猴病毒40早期启动子区域的定义以及猿猴病毒40 72碱基对重复序列增强效应中宿主范围偏向性的证明。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):721-5. doi: 10.1073/pnas.80.3.721.
8
Nucleotide sequence of the region encompassing the JC virus origin of DNA replication.包含JC病毒DNA复制起点区域的核苷酸序列。
J Virol. 1983 Apr;46(1):170-6. doi: 10.1128/JVI.46.1.170-176.1983.
9
Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication.猴病毒40 A蛋白-DNA复合物的拓扑结构：复制起点处五核苷酸相互作用位点的排列
J Virol. 1983 Apr;46(1):143-50. doi: 10.1128/JVI.46.1.143-150.1983.
10
The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements.SV40 72碱基对重复序列优先增强从近端天然或替代启动子元件起始的转录。
Cell. 1983 Feb;32(2):503-14. doi: 10.1016/0092-8674(83)90470-1.
Zotero 插件