Reisner Y, Sharon N, Haran-Ghera N
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2244-6. doi: 10.1073/pnas.77.4.2244.
Preleukemic bone marrow and spleen cells of irradiated C57BL/6 mice that were inoculated with the radiation-induced leukemia virus variant D-RadLV differ from autonomous end-stage leukemia cells in the expression of the receptor for peanut agglutinin. As a result, the preleukemic cells are agglutinated by peanut agglutinin and the end-stage cells are not. This observation provides further evidence that preleukemic cells possess surface markers similar to those of the prothymocyte. In vitro and in vivo thymocyte-virus interactions reveal that cells susceptible to D-RadLV transformation are present mainly among the peanut agglutinin-receptor-bearing thymocyte population which has previously been demonstrated to be immunologically immature.
接种辐射诱导白血病病毒变体D-RadLV的受辐照C57BL/6小鼠的白血病前期骨髓和脾细胞,在花生凝集素受体表达方面与自主性终末期白血病细胞不同。因此,白血病前期细胞被花生凝集素凝集,而终末期细胞则不被凝集。这一观察结果进一步证明,白血病前期细胞具有与前胸腺细胞相似的表面标志物。体外和体内胸腺细胞与病毒的相互作用表明,易受D-RadLV转化的细胞主要存在于携带花生凝集素受体的胸腺细胞群体中,此前已证明该群体在免疫上不成熟。