Human T cell response to Herpes simplex virus antigen in vitro.
作者信息
Berle E J, Thorsby E
出版信息
Acta Pathol Microbiol Scand C. 1980 Feb;88(1):31-7. doi: 10.1111/j.1699-0463.1980.tb00069.x.
Abstract
Herpes simplex virus type I antigen (HSV-Ag) added to T cells from individuals with clinical history of recurrent herpes labialis causes a proliferative response in vitro. This T cell response requires presensitization of the responding cell donor and will occur only in the presence of adherent cells (macrophages). The intensity of the response is closely related to the number of adherent cells present, being optimal at a ratio of 10:1 between T cells and adherent cells. Preliminary studies also indicate that the response to HVS-Ag is restricted by the HLA-D/DR determinants of the T cell donor.
摘要
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