人T细胞在体外对单纯疱疹病毒抗原的反应。
Human T cell response to Herpes simplex virus antigen in vitro.
作者信息
Berle E J, Thorsby E
出版信息
Acta Pathol Microbiol Scand C. 1980 Feb;88(1):31-7. doi: 10.1111/j.1699-0463.1980.tb00069.x.
Herpes simplex virus type I antigen (HSV-Ag) added to T cells from individuals with clinical history of recurrent herpes labialis causes a proliferative response in vitro. This T cell response requires presensitization of the responding cell donor and will occur only in the presence of adherent cells (macrophages). The intensity of the response is closely related to the number of adherent cells present, being optimal at a ratio of 10:1 between T cells and adherent cells. Preliminary studies also indicate that the response to HVS-Ag is restricted by the HLA-D/DR determinants of the T cell donor.
将I型单纯疱疹病毒抗原（HSV-Ag）添加到有复发性唇疱疹临床病史个体的T细胞中，可在体外引发增殖反应。这种T细胞反应需要反应性细胞供体预先致敏，并且仅在存在黏附细胞（巨噬细胞）的情况下才会发生。反应强度与存在的黏附细胞数量密切相关，当T细胞与黏附细胞的比例为10:1时反应最佳。初步研究还表明，对HSV-Ag的反应受T细胞供体的HLA-D/DR决定簇限制。
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