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人巨细胞病毒感染后早期人胚胎成纤维细胞中的促有丝分裂活性。

Mitogenic activity in human embryonic fibroblasts early after infection by human cytomegalovirus.

作者信息

Takehara N, Ryoke K, Kurimura T

出版信息

Infect Immun. 1982 Oct;38(1):375-9. doi: 10.1128/iai.38.1.375-379.1982.

DOI:10.1128/iai.38.1.375-379.1982
PMID:6292097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347741/
Abstract

We have characterized the nonspecific lymphocyte stimulation by extracts of human cytomegalovirus-infected human embryonic fibroblasts. Cell extracts prepared at 5 h postinfection (early extract) and 72 h postinfection (late extract) were both highly mitogenic in lymphocyte preparations from adult blood, cord blood, and rabbit blood. Maximum stimulation of the lymphocytes was observed on day 3 after the addition of early or late extract under optimal conditions. Early extract stimulated both the E-rosetting and the EAC-rosetting subpopulations of human lymphocytes. The mitogenic activity appeared before 5 h postinfection and was fairly stable at 30 degrees C for 5 h.

摘要

我们已经对人巨细胞病毒感染的人胚成纤维细胞提取物引起的非特异性淋巴细胞刺激作用进行了特性分析。在感染后5小时制备的细胞提取物（早期提取物）和感染后72小时制备的细胞提取物（晚期提取物），对来自成人血液、脐带血和兔血的淋巴细胞制剂均具有高度促有丝分裂活性。在最佳条件下添加早期或晚期提取物后第3天观察到淋巴细胞的最大刺激作用。早期提取物刺激人淋巴细胞的E玫瑰花结形成亚群和EAC玫瑰花结形成亚群。促有丝分裂活性在感染后5小时之前出现，并且在30℃下5小时相当稳定。

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