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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Acta Pathol Microbiol Scand C. 1980 Feb;88(1):7-13. doi: 10.1111/j.1699-0463.1980.tb00066.x.

Macrophage homogenate, added to the incubation medium of granulation tissue slices, decreases the incorporation of labelled proline to collagen and other proteins, to a greater extent in the presence of certain prostaglandins and in oxygen atmosphere, but to a lesser degree if serotonin and cyclic AMP are added. 2. Rheumatoid synovial fluid, connective tissue active peptide (CTAP) of Castor and an extract from CCl4-damaged liver stimulate collagen synthesis in the presence of macrophages. 3. Preparations from non-treated macrophages stimulate the incorporation of glucosamine to acid mucopolysaccharides, mainly hyaluronate. 4. In a developing rat granuloma, the formation of collagen was stimulated by homogenized macrophages and by macrophage culture medium, but especially by whole macrophages in the presence of SiO2.

巨噬细胞匀浆添加到肉芽组织切片的孵育培养基中，会降低标记脯氨酸掺入胶原蛋白和其他蛋白质的量，在某些前列腺素存在且处于氧气环境时这种降低程度更大，但如果添加血清素和环磷酸腺苷（cAMP），则降低程度较小。2. 类风湿性滑液、蓖麻的结缔组织活性肽（CTAP）以及四氯化碳损伤肝脏的提取物在巨噬细胞存在的情况下会刺激胶原蛋白合成。3. 未经处理的巨噬细胞制剂会刺激氨基葡萄糖掺入酸性粘多糖，主要是透明质酸盐。4. 在发育中的大鼠肉芽肿中，巨噬细胞匀浆和巨噬细胞培养基会刺激胶原蛋白的形成，但在二氧化硅存在时，完整的巨噬细胞刺激作用尤其明显。

Acta Pathol Microbiol Scand C. 1980 Feb;88(1):7-13. doi: 10.1111/j.1699-0463.1980.tb00066.x.

Macrophage homogenate, added to the incubation medium of granulation tissue slices, decreases the incorporation of labelled proline to collagen and other proteins, to a greater extent in the presence of certain prostaglandins and in oxygen atmosphere, but to a lesser degree if serotonin and cyclic AMP are added. 2. Rheumatoid synovial fluid, connective tissue active peptide (CTAP) of Castor and an extract from CCl4-damaged liver stimulate collagen synthesis in the presence of macrophages. 3. Preparations from non-treated macrophages stimulate the incorporation of glucosamine to acid mucopolysaccharides, mainly hyaluronate. 4. In a developing rat granuloma, the formation of collagen was stimulated by homogenized macrophages and by macrophage culture medium, but especially by whole macrophages in the presence of SiO2.

巨噬细胞匀浆添加到肉芽组织切片的孵育培养基中，会降低标记脯氨酸掺入胶原蛋白和其他蛋白质的量，在某些前列腺素存在且处于氧气环境时这种降低程度更大，但如果添加血清素和环磷酸腺苷（cAMP），则降低程度较小。2. 类风湿性滑液、蓖麻的结缔组织活性肽（CTAP）以及四氯化碳损伤肝脏的提取物在巨噬细胞存在的情况下会刺激胶原蛋白合成。3. 未经处理的巨噬细胞制剂会刺激氨基葡萄糖掺入酸性粘多糖，主要是透明质酸盐。4. 在发育中的大鼠肉芽肿中，巨噬细胞匀浆和巨噬细胞培养基会刺激胶原蛋白的形成，但在二氧化硅存在时，完整的巨噬细胞刺激作用尤其明显。