Matsubara S, Horiuchi J, Shibuya H, Sasaki M S
Acta Radiol Oncol. 1980;19(1):45-54. doi: 10.3109/02841868009130135.
The peripheral lymphocytes from irradiated patients generally have a reduced capability to respond to phytohemagglutinin (PHA). Whether a relationship exists between PHA-responsiveness and chromosome aberration frequencies was examined by washing the lymphocytes with culture medium. The results indicate that the defect in lymphocyte activation in patients receiving radiation therapy was caused by some reversible changes in the lymphocyte membrane directly associated with radiation exposure rather than by a radiation induced suppressor substance secondarily acting on the lymphocyte membrane.
接受过辐射的患者外周淋巴细胞对植物血凝素（PHA）的反应能力通常会降低。通过用培养基洗涤淋巴细胞，研究了PHA反应性与染色体畸变频率之间是否存在关联。结果表明，接受放射治疗患者的淋巴细胞激活缺陷是由与辐射暴露直接相关的淋巴细胞膜上的一些可逆变化引起的，而非由辐射诱导的抑制物质继发作用于淋巴细胞膜所致。
