Zahradnik J M, Spencer M J, Porter D D
Am J Med. 1980 May;68(5):725-32. doi: 10.1016/0002-9343(80)90262-4.
Illness associated adenovirus infection is described in 15 immunocompromised patients. Patients were immunocompromised by severe underlying disease, immunosuppressive or corticosteroid therapy or by age (prematurity). Evidence of adenovirus infection was obtained by either viral isolation or, in two cases, characteristic adenovirus inclusion bodies at postmortem study. All clinical illness was associated with high fever (temperature greater than 39 degrees C). Eighty per cent of the patients had severe systemic complaints including malaise, lethargy, fatigue and night sweats; a similar number of gastrointestinal symptoms. Pulmonary complaints were described in 11 of 15 cases and included cough (67 per cent) and tachypnea (53 per cent). Roentgenologic evidence of pneumonia was demonstrated in 12 of 15 patients (80 per cent). Elevation of serum hepatic enzyme levels (serum glutamic pyruvic transaminase (SGPT)) occurred in eight of 11 patients (73 per cent) and was moderate to severe (serum glutamic pyruvic transaminase greater than 450 IU/liter) in five of 11 (45 per cent). Nine patients died; seven after a rapid downhill course and two after a prolonged illness. Evidence of adenovirus infection microscopically by autopsy in the lung, liver or both is demonstrated in four patients with fulminant systemic illness. Adenovirus infection should be considered in the etiology of severe overwhelming illness in the immunocompromised host.
本文描述了15例免疫功能低下患者发生的与疾病相关的腺病毒感染。这些患者因严重基础疾病、免疫抑制或皮质类固醇治疗或年龄因素（早产）导致免疫功能低下。腺病毒感染的证据通过病毒分离获得，或在两例尸检研究中发现特征性的腺病毒包涵体。所有临床疾病均伴有高热（体温高于39摄氏度）。80%的患者有严重的全身症状，包括不适、嗜睡、疲劳和盗汗；胃肠道症状的患者数量与之相似。15例中有11例出现肺部症状，包括咳嗽（67%）和呼吸急促（53%）。15例患者中有12例（80%）有肺炎的影像学证据。11例患者中有8例（73%）血清肝酶水平（血清谷丙转氨酶（SGPT））升高，其中11例中有5例（45%）为中度至重度升高（血清谷丙转氨酶大于450 IU/升）。9例患者死亡；7例病情迅速恶化，2例病程迁延。4例暴发性全身疾病患者经尸检在肺、肝或两者中显微镜下证实有腺病毒感染。免疫功能低下宿主发生严重压倒性疾病的病因应考虑腺病毒感染。
