Sircar B, Johnson L R, Lichtenberger L M
Am J Physiol. 1980 Apr;238(4):G376-83. doi: 10.1152/ajpgi.1980.238.4.G376.
When rats were fed isocaloric amounts of chemically defined diets with variable amounts of protein (8-60%) or fat (0-30%) over a 10-day period, their serum and antral gastrin concentrations were, respectively, 60 and 40% lower than the levels of chow-fed rats. It was also determined that neither the low bulk content of these diets nor their inability to adequately buffer the gastric pH contributed to this response. The time course of this dietary-induced reduction in gastrin levels was investigated and it was found that the serum hormone levels were significantly reduced as early as 1-2 h after chow-fed rats were placed on these chemically defined diets. Antral gastrin levels were maintained at normal levels for 4-5 days after rats started consuming these synthetic diets and fell thereafter. With all of the chemically defined diets tested, the gastrin secretory response to a meal was significantly reduced. It therefore appears that synthetic diets lack some undefined food constituent present in chow that is required for the normal postprandial release of gastrin or, alternatively, that they contain an inhibitory factor which blocks the normal secretory response.
在10天的时间里，给大鼠喂食热量相等但蛋白质含量（8%-60%）或脂肪含量（0%-30%）不同的化学合成饲料，它们的血清和胃窦胃泌素浓度分别比喂食普通饲料的大鼠低60%和40%。研究还发现，这些饲料的低容积含量及其对胃pH值的缓冲不足均与这种反应无关。对这种饮食诱导的胃泌素水平降低的时间进程进行了研究，发现喂食普通饲料的大鼠食用这些化学合成饲料后1-2小时，血清激素水平就显著降低。大鼠开始食用这些合成饲料后，胃窦胃泌素水平在4-5天内维持在正常水平，此后下降。在所有测试的化学合成饲料中，对进食的胃泌素分泌反应均显著降低。因此，似乎合成饲料缺乏普通饲料中存在的某些未明确的食物成分，而这些成分是正常餐后胃泌素释放所必需的，或者说，它们含有一种抑制因子，可阻断正常的分泌反应。
