Ekeke N U, Shaw C, Johnston C F, Buchanan K D, Love A H
Department of Medicine, Queen's University of Belfast.
Br J Nutr. 1993 Jan;69(1):151-7. doi: 10.1079/bjn19930017.
The effect of dietary fats on gastrin in the pyloric antrum and plasma of Wistar rats was examined. Two different age-groups of rats were fed on three different diets in which fat was in the form of menhaden oil (MO), hydrogenated coconut oil (CO) and safflower oil (SO) respectively. Control groups were fed on normal laboratory diet. Each diet was isoenergetic and no group showed significant differences in either food intake or weight gain during the experiment. Weaner rats fed on the MO diet exhibited significant reductions in both antral (P = 0.047) and plasma (P = 0.002) gastrin concentrations when compared with age-matched controls. Likewise, adult rats fed on the MO diet exhibited significant reductions in both antral (P = 0.008) and plasma (P = 0.002) gastrin concentrations. In addition, adult rats fed on the CO diet exhibited significant reductions in both antral (P = 0.047) and plasma gastrin (P = 0.002) concentrations. Rats from both age-groups fed on the SO diet exhibited no significant differences in gastrin concentrations when compared with their respective control groups. These findings indicate that the composition of dietary fat can have profound effects on both tissue and plasma concentrations of gastrin in rats.
研究了膳食脂肪对Wistar大鼠幽门窦和血浆中胃泌素的影响。将两个不同年龄组的大鼠分别喂以三种不同的饮食，其中脂肪分别以鲱鱼油（MO）、氢化椰子油（CO）和红花油（SO）的形式存在。对照组喂以正常实验室饮食。每种饮食的能量相同，在实验期间，任何一组在食物摄入量或体重增加方面均未显示出显著差异。与年龄匹配的对照组相比，喂食MO饮食的断奶大鼠胃窦（P = 0.047）和血浆（P = 0.002）胃泌素浓度均显著降低。同样，喂食MO饮食的成年大鼠胃窦（P = 0.008）和血浆（P = 0.002）胃泌素浓度也显著降低。此外，喂食CO饮食的成年大鼠胃窦（P = 0.047）和血浆胃泌素（P = 0.002）浓度均显著降低。与各自的对照组相比，两个年龄组喂食SO饮食的大鼠胃泌素浓度均无显著差异。这些发现表明，膳食脂肪的组成可对大鼠胃泌素的组织和血浆浓度产生深远影响。
