Schneider E, Fuchs U, Schneider G, Helbig W
Exp Pathol (Jena). 1980;18(1):75-9. doi: 10.1016/s0014-4908(80)80073-1.
Phagocytosis of inert, radioactive gold particles in the reticuloendothelial system in rats in the case of experimental insulinopenic diabetes was studied. In the spleen, phagocytosis was seen to have fallen to a relatively low level after four weeks from the induction of diabetes. In the liver, there was noted a reduction of phagocytosis per gram of organ, though it remained the same for the total organ which in the case of diabetes mellitus increases in weight relative to body weight. This difference in reaction of the reticuloendothelial system in the liver and spleen has also been observed in mice with tumors. The importance of the findings of the present study for increased sensitivity to infections of poorly controlled diabetic patients is discussed in greater detail.
研究了实验性胰岛素缺乏糖尿病大鼠网状内皮系统对惰性放射性金颗粒的吞噬作用。在脾脏中，糖尿病诱导四周后，吞噬作用降至相对较低水平。在肝脏中，每克器官的吞噬作用有所降低，尽管相对于体重而言，糖尿病时肝脏重量增加，肝脏整体的吞噬作用仍保持不变。在患有肿瘤的小鼠中也观察到了肝脏和脾脏网状内皮系统反应的这种差异。本研究结果对于控制不佳的糖尿病患者对感染敏感性增加的重要性进行了更详细的讨论。
