Schneider E, Fuchs U, vom Scheidt J, Kämpfer I, Schneider G
Exp Pathol. 1982;22(3):149-55. doi: 10.1016/s0232-1513(82)80002-9.
Because of a reduction in the rate of phagocytosis by the reticuloendothelial system, the removal of large doses of colloids from the blood is much slower in rats with experimentally induced insulinopenic diabetes than in controls having a normal metabolism. This kinetics corresponds to the exponential response reported in the literature for an injected dose exceeding the "critical dose", with phagocytosis being a crucial parameter. In the case of smaller doses of colloids, however, clearance follows a different kinetic pattern which is here formulated mathematically. It is determined largely by the rate of liver blood flow. In this case, it is not possible to obtain statistical evidence of differences between diabetic and normal rats on administration of gold. Colloidal gold and so-called biological ink proved themselves extremely useful for quantitative studies of phagocytosis, whereas indium proved to be unsuitable under the experimental conditions used in these studies.
由于网状内皮系统吞噬作用速率降低，实验性诱导胰岛素缺乏性糖尿病大鼠从血液中清除大剂量胶体的速度比代谢正常的对照大鼠慢得多。这种动力学与文献中报道的注射剂量超过“临界剂量”时的指数反应相对应，吞噬作用是一个关键参数。然而，对于较小剂量的胶体，清除遵循不同的动力学模式，本文对其进行了数学公式化。它在很大程度上由肝血流速率决定。在这种情况下，给糖尿病大鼠和正常大鼠注射金后，无法获得两者之间差异的统计学证据。胶体金和所谓的生物墨水在吞噬作用的定量研究中证明非常有用，而在这些研究使用的实验条件下，铟被证明不适用。
