Bartl W, Breitenecker G, Kemeter P, Tatra G
Geburtshilfe Frauenheilkd. 1980 Apr;40(4):319-25. doi: 10.1055/s-2008-1037344.
Eighteen women received for four weeks daily applications of conjugated estrogens in ointment. Seven had had primary irradiation of carcinoma of the cervix and eleven were in the menopausal stage without irradiation. Before the first medication and 1, 2, 4, 6, 8, 12 and 24 hours afterwards the estradiol, FSH and LH levels were estimated and the mean values of the two collectives compared. Cytologic smears of the vaginal wall were taken weekly of three irradiated and seven not irradiated patients. From the results one can draw the conclusion that an absorption of the estrogens through the vaginal wall takes place leading to local as well as systemic effects of the estrogens. However in the radiated patients the absorption of estrogen and maturation of the epithelium was significantly slower than in the not-irradiated group.
18名女性连续四周每天使用结合雌激素软膏。其中7名曾接受过子宫颈癌的初次放疗，11名处于绝经阶段且未接受过放疗。在首次用药前以及用药后1、2、4、6、8、12和24小时，对雌二醇、促卵泡激素（FSH）和促黄体生成素（LH）水平进行了测定，并比较了两组人群的平均值。每周对3名接受放疗和7名未接受放疗的患者进行阴道壁细胞学涂片检查。从结果可以得出结论，雌激素可通过阴道壁吸收，从而产生雌激素的局部和全身作用。然而，放疗患者中雌激素的吸收和上皮细胞的成熟明显慢于未放疗组。
