Greenberg H, Penney L L, Smith M L
Gynecol Oncol. 1984 Mar;17(3):301-7. doi: 10.1016/0090-8258(84)90215-4.
Serum concentrations of unconjugated estrone (E1) and 17 beta-estradiol (E2) have been measured in eight patients before and after 1.25 mg of conjugated estrogens administered intravaginally. The measurements were repeated using 2 mg of micronized estradiol administered intravaginally 1 week later to six of the women and 7 months later in one. All the patients had completed a full course of irradiation for pelvic malignancy at least 8 months prior to the study. Baseline, 1/2, 1-, 2-, 4-, 8-, and 24-hr samples were analyzed. After conjugated estrogens mean serum E2 increased 4.5-fold to peak at 163 pg/ml at 2 hr while serum E1 increased 3.2-fold to peak at 222 pg/ml at 2 hr. After micronized E2 mean serum E2 increased 89.3-fold to peak at 1250 pg/ml at 1 hr while E1 increased 3.1-fold to peak at 416 pg/ml at 2 hr. These data indicate that rapid absorption of E1 and E2 occurs through irradiated vaginal mucosa.
在8名患者阴道内给予1.25mg结合雌激素前后，测定了血清中未结合雌酮（E1）和17β-雌二醇（E2）的浓度。1周后，对其中6名女性阴道内给予2mg微粒化雌二醇，1名女性在7个月后给予，重复进行测量。所有患者在研究前至少8个月已完成盆腔恶性肿瘤的全疗程放疗。分析了基线、1/2、1、2、4、8和24小时的样本。给予结合雌激素后，血清E2平均增加4.5倍，在2小时时达到峰值163pg/ml，而血清E1增加3.2倍，在2小时时达到峰值222pg/ml。给予微粒化E2后，血清E2平均增加89.3倍，在1小时时达到峰值1250pg/ml，而E1增加3.1倍，在2小时时达到峰值416pg/ml。这些数据表明，E1和E2可通过受照射的阴道黏膜快速吸收。
