腺病毒2型DNA右手末端SmaI-K片段的核苷酸序列。

The nucleotide sequence of the right-hand terminal SmaI-K fragment of adenovirus type 2 DNA.

作者信息

Shinagawa M, Padmanabhan R V, Padmanabhan R

出版信息

Gene. 1980 Apr;9(1-2):99-114. doi: 10.1016/0378-1119(80)90169-9.

Abstract

The primary structure of the SmaI-K fragment of adenovirus type 2 (Ad2) DNA has been determined. This region includes one of the origins of DNA replication (Winnacker, 1978; Sussenbach and Kuijk, 1978). A leader sequence for an early mRNA in region 4 (Berk and Sharp, 1977; 1978) has also been mapped in this region. The comparison of the primary structure of this region in Ad2 DNA with the corresponding region in Ad5 DNA shows a remarkable homology which may be significant in view of the fact that Ad2 and Ad5 DNAs can interchangeably function in the in vitro replication system of Challberg and Kelly (1979).

摘要

已确定2型腺病毒（Ad2）DNA的SmaI-K片段的一级结构。该区域包括DNA复制起点之一（温纳克，1978年；苏森巴赫和库伊克，1978年）。区域4中一种早期mRNA的前导序列（伯克和夏普，1977年；1978年）也已在此区域定位。将Ad2 DNA中该区域的一级结构与Ad5 DNA中的相应区域进行比较，发现有显著的同源性，鉴于Ad2和Ad5 DNA可在查尔伯格和凯利（1979年）的体外复制系统中互换功能，这一同源性可能具有重要意义。