Gutjahr P
Fortschr Med. 1980 Feb 28;98(8):289-92.
Throughout the past years, permanent cure has become the realistic goal of treatment in a great number of children with cancer. As therapy is aggressive, various late effects of treatment have to be considered. The long-term survivors of 668 children with cancer treated at the Dept. of Pediatrics, University of Mainz, were analyzed for: their present clinical and neurological status, sensory function, impaired skeletal growth, risk of cardiomyopathies, renal functions after treatment for Wilms' tumors, chronic hepatitis, endocrine disorders, electroencephalographic abnormalities, motor and sensory nerve conduction velocities, death as a late consequence of tumor therapy, risk of second malignant neoplasias, and their psychosocial and intellectual situation. As a general result, the number of possible late consequences is great. Cancer treatment of children should be restricted to specialized teams at pediatric tumor centers. This is important concerning an optimal therapy as well as long-term care in view of prevention and early detection and treatment of late sequelae of tumors and treatment.
在过去的几年里，根治已成为众多癌症患儿治疗的现实目标。由于治疗手段积极，必须考虑治疗的各种晚期效应。对美因茨大学儿科治疗的668例癌症患儿的长期存活者进行了分析，内容包括：他们目前的临床和神经状况、感觉功能、骨骼生长受损情况、患心肌病的风险、肾母细胞瘤治疗后的肾功能、慢性肝炎、内分泌紊乱、脑电图异常、运动和感觉神经传导速度、肿瘤治疗的晚期死亡后果、患第二种恶性肿瘤的风险，以及他们的心理社会和智力状况。总的结果是，可能出现的晚期后果数量众多。儿童癌症治疗应限于儿科肿瘤中心的专业团队。鉴于肿瘤及治疗晚期后遗症的预防、早期发现和治疗，这对于优化治疗以及长期护理而言都很重要。
