Ashida Y, Saijo T, Kuriki H, Maki Y
Int Arch Allergy Appl Immunol. 1980;62(4):415-22. doi: 10.1159/000232544.
AA-344, which has been evidenced to inhibit selectively IgE-mediated allergic reactions, exhibited an inhibitory effect on cyclic AMP phosphodiesterase (PDase) in the homogenates of purified rat peritoneal mast cells (RMC). AA-344 showed synergistic effects with epinephrine, isoproterenol or prostaglandin E2 and F2 alpha in increasing cyclic AMP level in RMC: the combinations caused an increase in cyclic AMP 30-160 times as much as that caused by the respective agent alone. In the latter effect, AA-344 was at least 1,000 times as potent as theophylline. On the other hand, histamine or serotonin with or without AA-344 had no effect on the RMC cyclic AMP. These results obtained in vitro suggest that AA-344 may exert antiallergic action by increasing cyclic AMP via an interaction with epinephrine or prostaglandins which might be endogenously involved in regulation of a function of RMC in allergic reactions.
已证实能选择性抑制IgE介导的过敏反应的AA - 344，对纯化的大鼠腹膜肥大细胞（RMC）匀浆中的环磷酸腺苷磷酸二酯酶（PDase）表现出抑制作用。AA - 344与肾上腺素、异丙肾上腺素或前列腺素E2和F2α在提高RMC中环磷酸腺苷水平方面具有协同作用：这些组合导致环磷酸腺苷增加的量是各自单独使用药物时的30 - 160倍。在后一种作用中，AA - 344的效力至少是茶碱的1000倍。另一方面，无论有无AA - 344，组胺或5 - 羟色胺对RMC中的环磷酸腺苷均无影响。这些体外实验结果表明，AA - 344可能通过与肾上腺素或前列腺素相互作用增加环磷酸腺苷来发挥抗过敏作用，而肾上腺素或前列腺素可能内源性参与过敏反应中RMC功能的调节。
