Endoh M, Yanagisawa T, Taira N
Tohoku J Exp Med. 1980 Feb;130(2):199-201. doi: 10.1620/tjem.130.199.
The effect of a potent coronary vasodilator, SG-75, on the purified cyclic AMP phosphodiesterase of the bovine heart was compared with that of papaverine. SG-75 inhibited the phosphodiesterase activity in a competitive manner, the IC50 being 10 mM. SG-75 was approximately 300 times less potent than papaverine in inhibiting the phosphodiesterase activity. Thus, it is unlikely that the phosphodiesterase inhibition by SG-75 is involved in its vasodilator action.
将一种强效冠状动脉血管扩张剂SG - 75对牛心脏纯化环磷酸腺苷磷酸二酯酶的作用与罂粟碱进行了比较。SG - 75以竞争性方式抑制磷酸二酯酶活性，半数抑制浓度（IC50）为10 mM。在抑制磷酸二酯酶活性方面，SG - 75的效力约为罂粟碱的300分之一。因此，SG - 75对磷酸二酯酶的抑制作用不太可能涉及其血管扩张作用。
