向心脏浦肯野纤维细胞内注射氢离子对电偶联的影响。

Influence of intracellular injection of H+ on the electrical coupling in cardiac Purkinje fibres.

作者信息

De Mello W C

出版信息

Cell Biol Int Rep. 1980 Jan;4(1):51-8. doi: 10.1016/0309-1651(80)90009-0.

Abstract

The effect of intracellular injection of H+ on the electrical coupling of canine Purkinje cells was investigated. It was found that H+ increased the intracellular resistance (ri) and caused electrical uncoupling. The effect of high (H+)i on cell communication was partially reverted by intracellular injection of EDTA. These observations seem to indicate that the effect of low pHi on the electrical coupling can be explained, at least in part, by a rise in free [Ca2+]i. Further studies are required.

摘要

研究了向犬浦肯野细胞内注射H⁺对其电偶联的影响。发现H⁺增加了细胞内电阻（ri）并导致电解偶联。细胞内注射EDTA可部分逆转高（H⁺）i对细胞通讯的影响。这些观察结果似乎表明，低细胞内pH值对电偶联的影响至少部分可以用游离[Ca²⁺]i的升高来解释。还需要进一步的研究。