猴痘病毒白色痘疱（h）突变体与亲代猴痘病毒以及从动物中分离出的类天花病毒的比较。

Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals.

作者信息

Dumbell K R, Archard L C

出版信息

Nature. 1980 Jul 3;286(5768):29-32. doi: 10.1038/286029a0.

Abstract

Monkeypox mutants arising spontaneously or after serial, high multiplicity passage were characterized phenotypically and by restriction endonuclease mapping. Some resemble "whitepox" and variola viruses in several of the markers tested but all are distinguishable phenotypically from these. None resembles "whitepox" viruses in genome structure although near-terminal deletions or symmetrical, terminal rearrangements, relative to parental monkeypox, occurred. "Whitepox" viruses isolated from animals closely resemble variola in both phenotype and genome structure.

摘要

对自发产生或经连续高倍传代后出现的猴痘突变体进行了表型特征分析和限制性内切酶图谱分析。在测试的一些标志物中，有些类似于“白痘”病毒和天花病毒，但在表型上均与它们有区别。尽管相对于亲本猴痘发生了近末端缺失或对称的末端重排，但在基因组结构上没有一种类似于“白痘”病毒。从动物中分离出的“白痘”病毒在表型和基因组结构上都与天花非常相似。