Bisgard G E, Forster H V, Klein J P, Manohar M, Bullard V A
Respir Physiol. 1980 Jun;40(3):379-92. doi: 10.1016/0034-5687(80)90036-5.
Dopamine (DA) given IV by bolus injection (5, 10, 20 micrograms/kg) and by slow IV infusion (20 micrograms . kg . min) depressed VE significantly in awake normoxic goats. These responses were attenuated but not eliminated during hypoxia (FIO2 = 0.14) and hyperoxia (FIO2 = 1.0). After administering haloperidol (0.3 mg/kg) or removing the carotid bodies (CBE) there was greater attenuation of the response to DA. In normal goats haloperidol also caused a significant increase in ventilatory response to acute hypoxia and exaggerated depression of VE after 3--5 breaths O2 during steady-state hypoxia. After CBE haloperidol caused mild hypoventilation (delta PaCO2 = +2.5 Torr). CBE induced hypoventilation in goats (delta PaCO2 = +7.8 Torr) and reduced, but did not totally eliminate, peripheral chemoreceptor responses to acute stimuli (NaCN injection, transient N2 and transient O2 breathing). Attempted aortic body denervation did not eliminate these residual responses. We conclude: (1) DA may function as a modulator of carotid body (CB) function in the goat, (2) there may be central excitatory DA receptors in the goat, (3) the CB is important in regulating resting ventilation in the goat.
通过大剂量静脉注射（5、10、20微克/千克）和静脉缓慢输注（20微克·千克·分钟）给予多巴胺（DA），可使清醒的常氧山羊的每分钟通气量（VE）显著降低。在缺氧（FIO2 = 0.14）和高氧（FIO2 = 1.0）期间，这些反应减弱但未消除。给予氟哌啶醇（0.3毫克/千克）或切除颈动脉体（CBE）后，对DA的反应减弱更明显。在正常山羊中，氟哌啶醇还会导致对急性缺氧的通气反应显著增加，以及在稳态缺氧期间吸入3 - 5次氧气后VE的过度降低。切除CBE后，氟哌啶醇会引起轻度通气不足（△PaCO2 = +2.5托）。切除CBE会导致山羊通气不足（△PaCO2 = +7.8托），并降低但未完全消除外周化学感受器对急性刺激（注射氰化钠、短暂吸入氮气和短暂吸入氧气）的反应。尝试去主动脉体神经支配并不能消除这些残余反应。我们得出以下结论：（1）DA可能在山羊中作为颈动脉体（CB）功能的调节剂；（2）山羊体内可能存在中枢兴奋性DA受体；（3）CB在调节山羊静息通气中很重要。
