Tobin G R, Chvapil M, Gildenberg P L
Surgery. 1980 Aug;88(2):231-8.
Kinetics of collagen synthesis and deposition were studied in the canine spinal cord, pia mater, and dura mater and in wounds of these tissues over the first 8 weeks. Little collagen is present in unwounded spinal cord compared with surrounding mesenchymal membranes. Collagen synthetic potential was found within the spinal cord, a tissue of neurectodermal origin. Rate of collagen synthesis per collagen content in the unwounded spinal cord was high. This synthetic rate was as high as that of wounds at their maximum collagen synthetic rates. Substantial deposition of collagen followed spinal cord wounding. Wounding the spinal cord, pia mater, and dura mater caused substantial elevations in rates of collagen synthesis in each tissue. These synthetic rates remained at maximum levels throughout the 8-week study, a prolonged period when compared with other wounded tissues previously studied. The role of mesenchymal tissue physiology in central nervous system wound healing is discussed. The potential value of these findings for further studies and for experimental manipulation of the healing process in spinal cord and central nervous system wounds is presented. Implications of these findings on the hypothetical relationship of scar to spinal cord and central nervous system regeneration are noted.
在最初的8周内，对犬脊髓、软脑膜和硬脑膜以及这些组织的伤口处的胶原蛋白合成和沉积动力学进行了研究。与周围的间充质膜相比，未受伤的脊髓中胶原蛋白含量很少。在神经外胚层起源的脊髓组织中发现了胶原蛋白合成潜力。未受伤脊髓中每单位胶原蛋白含量的合成速率很高。该合成速率与伤口在最大胶原蛋白合成速率时的速率一样高。脊髓受伤后有大量胶原蛋白沉积。脊髓、软脑膜和硬脑膜受伤导致每个组织中的胶原蛋白合成速率大幅升高。在整个8周的研究中，这些合成速率一直保持在最高水平，与之前研究的其他受伤组织相比，这是一个较长的时期。讨论了间充质组织生理学在中枢神经系统伤口愈合中的作用。介绍了这些发现对进一步研究以及对脊髓和中枢神经系统伤口愈合过程进行实验操作的潜在价值。指出了这些发现对疤痕与脊髓和中枢神经系统再生之间假设关系的影响。
