支原体可消除抗体介导的病毒中和作用。
Antibody-mediated neutralization of virus is abrogated by mycoplasma.
作者信息
Dickson C, Elkington J, Hales A, Weiss R
出版信息
Infect Immun. 1980 Jun;28(3):649-53. doi: 10.1128/iai.28.3.649-653.1980.
Abstract
The ability of a mouse mammary tumor cell line to abrogate antibody neutralization of vesicular stomatitis virus was shown to be due to the presence of mycoplasma. The mycoplasma was isolated from the cell line and typed as Mycoplasma orale. Colonies of this mycoplasma were used to deliberately infect cell cultures which then gained the capacity to reactivate antibody-neutralized virus. The extent of the reactivation depended on the source of neutralizing antiserum. Other species of mycoplasma were tested and were found to reactivate neutralized virus, indicating that this may be a general phenomenon of mycoplasma contamination.
摘要
已证明一种小鼠乳腺肿瘤细胞系消除水泡性口炎病毒抗体中和作用的能力是由于支原体的存在。从该细胞系中分离出支原体，并鉴定为口腔支原体。用这种支原体的菌落故意感染细胞培养物，这些细胞培养物随后获得了重新激活被抗体中和的病毒的能力。重新激活的程度取决于中和抗血清的来源。对其他支原体物种进行了测试，发现它们也能重新激活被中和的病毒，这表明这可能是支原体污染的普遍现象。
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