Sommerfelt M A, Williams B P, McKnight A, Goodfellow P N, Weiss R A
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
J Virol. 1990 Dec;64(12):6214-20. doi: 10.1128/JVI.64.12.6214-6220.1990.
Simian retrovirus (SRV) serotypes 1 to 5 are exogenous type D viruses causing immune suppression in macaque monkeys. These viruses exhibit receptor interference with each other, with two endogenous type D viruses of the langur (PO-1-Lu) and squirrel monkey, and with two type C retroviruses, feline endogenous virus (RD114/CCC) and baboon endogenous virus (BaEV), indicating that each utilizes the same cell surface receptor (M. A. Sommerfelt and R. A. Weiss, Virology 176:58-69, 1990). Vesicular stomatitis virus pseudotype particles bearing envelope glycoproteins of RD114, BaEV, and the seven SRV strains were employed to detect receptors expressed in human-rodent somatic cell hybrids segregating human chromosomes. The only human chromosome common to all the susceptible hybrids was chromosome 19. By using hybrids retaining different fragments of chromosome 19, a provisional subchromosomal localization of the receptor gene was made to 19q13.1-13.2. Antibodies previously reported to be specific to a BaEV receptor (L. Thiry, J. Cogniaux-Leclerc, R. Olislager, S. Sprecher-Goldberger, and P. Burkens, J. Virol. 48:697-708, 1983) did not block BaEV, RD114, or SRV pseudotypes or syncytia. Antibodies to known surface markers determined by genes mapped to chromosome 19 did not block virus-receptor interaction. The identity of the receptor remains to be determined.
猿猴逆转录病毒（SRV）1至5型是外源性D型病毒，可导致猕猴免疫抑制。这些病毒彼此之间以及与叶猴（PO-1-Lu）和松鼠猴的两种内源性D型病毒，以及与两种C型逆转录病毒，猫内源性病毒（RD114/CCC）和狒狒内源性病毒（BaEV）存在受体干扰，这表明它们都利用相同的细胞表面受体（M. A. Sommerfelt和R. A. Weiss，《病毒学》176:58 - 69，1990）。携带RD114、BaEV包膜糖蛋白以及七种SRV毒株的水疱性口炎病毒假型颗粒被用于检测在分离人类染色体的人 - 啮齿动物体细胞杂种中表达的受体。所有易感杂种共有的唯一人类染色体是19号染色体。通过使用保留19号染色体不同片段的杂种，将受体基因初步亚染色体定位到19q13.1 - 13.2。先前报道对BaEV受体具有特异性的抗体（L. Thiry、J. Cogniaux - Leclerc、R. Olislager、S. Sprecher - Goldberger和P. Burkens，《病毒学杂志》48:697 - 708，1983）并未阻断BaEV、RD114或SRV假型或合胞体。由定位到19号染色体的基因所确定的已知表面标志物的抗体并未阻断病毒 - 受体相互作用。受体的身份仍有待确定。
