孕期人多瘤病毒感染的前瞻性研究。

A prospective study of human polyomavirus infection in pregnancy.

作者信息

Coleman D V, Wolfendale M R, Daniel R A, Dhanjal N K, Gardner S D, Gibson P E, Field A M

出版信息

J Infect Dis. 1980 Jul;142(1):1-8. doi: 10.1093/infdis/142.1.1.

DOI:10.1093/infdis/142.1.1

Abstract

Urine samples from 1,235 pregnant women were examined by light microscopy for cytologic evidence of virus infection. Smears of urine sediment from 40 women (3.2%) were observed to contain inclusion-bearing cells; polyomavirus infection was confirmed by virologic methods in 24 (60%). A polyomavirus was isolated from 12 women. Five isolates were identified as JC virus and one as BK virus. Another isolate designated AS virus appeared to be unique. Serologic studies on the 40 women were consistent with a high frequency of reactivation of JC virus, and virus excretion was related to gestation. The evidence suggests that selective excretion of JC virus may occur in pregnancy. Among 390 pregnant women without inclusion-bearing cells in their urine, 78 (20%) had a high or rising titer of serum antibody to JC or BK virus or both, a result suggesting virus reactivation, but virus excretion was not detected. In contrast to other reports, no evidence was found for transmission of BK virus to the fetus.

摘要

对1235名孕妇的尿液样本进行光学显微镜检查，以寻找病毒感染的细胞学证据。观察到40名女性（3.2%）的尿沉渣涂片含有包涵体细胞；通过病毒学方法在24名（60%）女性中证实了多瘤病毒感染。从12名女性中分离出多瘤病毒。5株分离株被鉴定为JC病毒，1株为BK病毒。另一株命名为AS病毒的分离株似乎是独特的。对这40名女性的血清学研究表明JC病毒再激活频率很高，且病毒排泄与妊娠有关。有证据表明妊娠期间可能会出现JC病毒的选择性排泄。在390名尿液中无包涵体细胞的孕妇中，78名（20%）的血清中抗JC或BK病毒或两者的抗体滴度较高或呈上升趋势，这一结果提示病毒再激活，但未检测到病毒排泄。与其他报告不同的是，未发现BK病毒传播给胎儿的证据。