Lindstrom J
J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):568-76. doi: 10.1136/jnnp.43.7.568.
Injection of animals with purified acetylcholine receptor in complete Freund's adjuvant causes development of antibodies which crossreact with receptors in muscle. The crossreacting antibodies impair neuromuscular transmission. Animals with experimental autoimmune myasthenia gravis (EAMG) are excellent models for studying the complex mechanisms by which the autoimmune response to receptor in myasthenia gravis causes muscle weakness. This review first briefly describes the discovery of EAMG. Then, to provide the necessary perspective, receptor structure and function and properties of anti-receptor antibodies are discussed, followed by a brief review of the pathological mechanisms in EAMG.
用完全弗氏佐剂中的纯化乙酰胆碱受体注射动物会导致产生与肌肉中的受体发生交叉反应的抗体。这些交叉反应抗体损害神经肌肉传递。实验性自身免疫性重症肌无力(EAMG)动物是研究重症肌无力中针对受体的自身免疫反应导致肌肉无力的复杂机制的优秀模型。本综述首先简要描述了EAMG的发现。然后,为提供必要的视角,讨论了受体结构与功能以及抗受体抗体的特性,接着简要回顾了EAMG的病理机制。