Pease L R, Murphy W H
Nature. 1980 Jul 24;286(5771):398-400. doi: 10.1038/286398a0.
Intraperitoneal injection of neuropathogenic strains of lactic dehydrogenase virus (LDV) causes a histologically distinctive fatal paralytic disease characterized by an inflammatory destruction of motor neurones in the brain stem and cord in C58 mice aged over 9 months. To elicit the disease in the naturally susceptible C58 strain requires an age-associated or X-ray induced loss of immunological competence, LDV infection and genetic susceptibility. Genetic studies of the common inbred mouse strains showed that susceptibility to the disease was not linked to the major histocompatibility complex but correlated with the FV-1n allele, susceptibility to spontaneous leukaemia, and infection by neuropathogenic strains of LDV. These observations suggested that neuropathogenic strains of LDV elicit the disease only in those strains of mice that carry multiple copies of N-tropic C-type retroviruses in their genomes and that are permissive for retrovirus replication. Presumably the expression of these viral genomes (high titres of virus in tissues correlating with age) is the important factor. Here we present genetic evidence to support this hypothesis and briefly discuss the possible implications.
腹腔注射神经致病性乳酸脱氢酶病毒（LDV）毒株会引发一种具有独特组织学特征的致命麻痹性疾病，其特点是9个月以上的C58小鼠脑干和脊髓中的运动神经元发生炎性破坏。要在天然易感的C58品系中引发这种疾病，需要与年龄相关的或X射线诱导的免疫能力丧失、LDV感染以及遗传易感性。对常见近交系小鼠品系的遗传学研究表明，对该疾病的易感性与主要组织相容性复合体无关，但与FV-1n等位基因、对自发性白血病的易感性以及神经致病性LDV毒株的感染相关。这些观察结果表明，神经致病性LDV毒株仅在那些基因组中携带多个N型嗜性C型逆转录病毒拷贝且允许逆转录病毒复制的小鼠品系中引发疾病。据推测，这些病毒基因组的表达（组织中病毒高滴度与年龄相关）是重要因素。在此，我们提供遗传学证据来支持这一假说，并简要讨论其可能的影响。
