Karmali R A
Prostaglandins Med. 1980 Jul;5(1):11-28. doi: 10.1016/0161-4630(80)90086-5.
This paper reviews work on the role of prostaglandins in cancer. A substantial body of evidence demonstrates elevated amounts of E series of prostaglandins in human and experimental tumors. Blockade of prostaglandin synthesis in vitro or in vivo results in inhibition of tumor growth. Involvement of prostaglandins is implicated in the actions of tumor promoters like phorbol and polycyclic aromatic hydrocarbon carcinogens. Symptoms like hypercalcemia, osteolysis and tumor metastasis are discussed where disordered synthesis and/or action of prostaglandins and related substances might have a role in the altered metabolism associated with neoplasia.
本文综述了前列腺素在癌症中作用的相关研究。大量证据表明，在人类肿瘤和实验性肿瘤中，E系列前列腺素的含量升高。在体外或体内阻断前列腺素合成会导致肿瘤生长受到抑制。前列腺素参与了佛波醇和多环芳烃致癌物等肿瘤促进剂的作用。文中讨论了高钙血症、骨质溶解和肿瘤转移等症状，其中前列腺素及相关物质的合成和/或作用紊乱可能在与肿瘤形成相关的代谢改变中发挥作用。
