Karmali R A, Welt S, Thaler H T, Lefevre F
Br J Cancer. 1983 Nov;48(5):689-96. doi: 10.1038/bjc.1983.251.
Tissue prostaglandin (PG) content and production by human breast cancers were measured in 24 human mammary carcinoma specimens. The 5 compounds studied were PGE1, PGE2, PGF2 alpha, 6-keto-PGF1 alpha, and TXB2. The tissue content of all 5 compounds was higher in neoplastic tissue in comparison with the paired noncancerous breast tissue. However, microsomal PG synthetase activity in vitro in noncancerous and neoplastic breast tissue was comparable. Increased thromboxane formation was associated with three clinical variables--tumour size, axillary lymph node metastases and distant metastasis. A lesion negative for either oestrogen or progesterone receptor content tended to produce more TXB2 but lower PGE2 and 6-keto-PGF1 alpha. Results obtained in this pilot study may provide clues as to what direction future larger studies could take in the search for reliable prognostic indicators for breast cancer.
在24份人乳腺癌标本中测量了人乳腺癌组织中前列腺素（PG）的含量及生成情况。所研究的5种化合物为前列腺素E1（PGE1）、前列腺素E2（PGE2）、前列腺素F2α（PGF2α）、6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（TXB2）。与配对的非癌性乳腺组织相比，所有这5种化合物在肿瘤组织中的含量均更高。然而，非癌性和肿瘤性乳腺组织中微粒体PG合成酶的体外活性相当。血栓素生成增加与三个临床变量相关——肿瘤大小、腋窝淋巴结转移和远处转移。雌激素或孕激素受体含量为阴性的病变倾向于产生更多的TXB2，但PGE2和6-酮-前列腺素F1α的含量较低。这项初步研究所得结果可能为未来更大规模研究在寻找乳腺癌可靠预后指标方面的研究方向提供线索。
