Carlson G P
Toxicol Lett. 1980 Aug;6(3):207-12. doi: 10.1016/0378-4274(80)90193-9.
The administration of doses as low as 0.78 mu mol/kg/day p.o. for 90 dys of the commercial fire retardants pentabromodiphenyl ehter and octabromodiphenyl ether to rats resulted in increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification and p-nitroanisole demethylation. This dose of pentabromodiphenyl ehter and higher doses of octabromodiphenyl ether also increased cytochrome P-450 and NADPH cytochrome c reductase. Measurements made at 30 and 60 days after the last dose showed that these indicators of induced xenobiotic metabolism return to control levels slowly. The results demonstrate that these inducers are not only potent but that their effects may be long-lasting.
给大鼠口服低至0.78微摩尔/千克/天的商用阻燃剂五溴二苯醚和八溴二苯醚，持续90天，结果导致对氧磷（EPN）解毒作用增强以及对硝基苯甲醚脱甲基作用增强。这个剂量的五溴二苯醚以及更高剂量的八溴二苯醚还会增加细胞色素P - 450和NADPH细胞色素c还原酶。在最后一剂后的30天和60天进行的测量表明，这些诱导异源物代谢的指标恢复到对照水平的速度很慢。结果表明，这些诱导剂不仅效力强大，而且其作用可能是持久的。
